Human pupillary dilatation after topical instillation of phenylephrine was assessed in a prospective, randomized, controlled experiment to measure alterations in α-end-organ responsivity after regular elicitation of the relaxation response. Baseline pupillometric measurements were taken in both experimental and control subjects. The experimental subjects then practiced daily a technique that elicited the relaxation response while the control subjects sat quietly for comparable periods of time without eliciting the relaxation response. After four to six weeks, both groups returned to the laboratory for an assessment identical to that of the first visit. Comparison between visits revealed that the pupillary dilatation in the experimental group was significantly diminished (p < .02) as compared to that of the control group. This observation is consistent with reduced end-organ responsivity to an exogenous α-adrenergic agent after regular elicitation of the relaxation response.
Reduced Pupillary Sensitivity to Topical Phenylephrine Associated with the Relaxation Response
Publication
Journal of Human Stress
Abstract
Web and Email Links
Related Listings
Journal
IEEE Access
Relaxation helps to reduce physical, mental, and emotional pressure. Relaxation techniques generally enable a person to obtain calmness and well-being by reducing stress, anxiety, or anger. When a person becomes calm the body reacts physiologically, producing the so-called Relaxation Response (RResp) which affects the organism in a positive manner, no matter if it is during a state of relaxation or in the middle of a stressful period. The goal of this paper is to design a system capab […]
Journal
Psychiatry
In the Western world today, there is a growing interest in nonpharmacological, self-induced, altered states of consciousness because of their alleged benefits of better mental and physical health and improved ability to deal with tension and stress. During the experience of one of these states, individuals claim to have feelings of increased creativity, of infinity, and of immortality; they have an evangelistic sense of mission, and report that mental physical suffering vanish (Dean). […]
Journal
Annals of the New York Academy of Sciences
Stress is a well-known risk factor in the development of addiction and in addiction relapse vulnerability. A series of population-based and epidemiological studies have identified specific stressors and individual-level variables that are predictive of substance use and abuse. Preclinical research also shows that stress exposure enhances drug self-administration and reinstates drug seeking in drug-experienced animals. The deleterious effects of early life stress, child maltreatment, a […]