Neurobiology of Stress

It is hypothesized that situations requiring continuous behavioral adjustment activate an integrated, hypothalamic response, the emergency reaction. The frequent elicitation of the physiologic changes associated with the emergency reaction has been implicated in the development of diseases such as hypertension. Prevention and treatment of these diseases may be through the use of the relaxation response, an integrated hypothalamic response whose physiologic changes appear to be the cou […]

In this study, Herbert Benson's (1975) Relaxation Response Meditation program was tested as a possible treatment for Irritable Bowel Syndrome (IBS). Participants were 16 adults who were matched into pairs based on presence of Axis I disorder, primary IBS symptoms and demographic features and randomized to either a six week meditation condition or a six week wait list symptom monitoring condition. Thirteen participants completed treatment and follow-up. All subjects assigned to the Wai […]

We previously reported reduced blood pressure, psychological symptoms, and other cardiac risk factors in hypertensive patients who participated in a nonpharmacologic, outpatient behavioral program. The present study is a 3 to 5 year follow-up of 59 (60%) of the same patients (who served as their own controls) to assess continued efficacy of the program. At entry into the study, patients had hypertension for a median of 6 years. Therefore, it is unlikely that placebo effect could expla […]