Neurobiology of Stress

A wakeful hypometabolic state may be induced by simple, non-cultic mental techniques or by traditional meditational practices. The hypometabolic state seems to represent an integrated hypothalamic response ("relaxation response") which is consistent with a state of decreased sympathetic-nervous-system activity. A prospective investigation was designed to test whether regular elicitation of the relaxation response might lower blood-pressures in hypertensive patients who were maintained […]

It is hypothesized that situations requiring continuous behavioral adjustment activate an integrated, hypothalamic response, the emergency reaction. The frequent elicitation of the physiologic changes associated with the emergency reaction has been implicated in the development of diseases such as hypertension. Prevention and treatment of these diseases may be through the use of the relaxation response, an integrated hypothalamic response whose physiologic changes appear to be the cou […]

Although the physiological and biochemical changes that occur during the acute stress response have been well-characterized, the contrasting changes that underlie the relaxation response evoked by various mind-body techniques are less understood. To help guide future mind-body research, we present a conceptual model that integrates patterns of change at the physiological and molecular levels. In addition, we point to future research opportunities and discuss how repeated elicitation o […]